Beneficial effects of n-acetylcysteine on ischaemic brain injury
✍ Scribed by Salvatore Cuzzocrea; Emanuela Mazzon; Giuseppina Costantino; Ivana Serraino; Laura Dugo; Giusy Calabrò; Giovanni Cucinotta; Angela De Sarro; A P Caputi
- Book ID
- 110005099
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 377 KB
- Volume
- 130
- Category
- Article
- ISSN
- 0007-1188
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## Abstract The influence of acetylcysteine (ac‐cys) on cisplatin (CP) nephrotoxicity was investigated in female Wistar rats. Administration of 0.6 mg CP 100 g^−1^ body wt. was followed by oliguria and proteinuria, as well as a significant increase of blood urea nitrogen concentration. The i.p. adm
We investigated whether intraportal injection of 150 mgkg N-acetylcysteine (NAC) into rats reduced hepatic ischemia-reperfusion injury after 48 hours of cold storage and 2 hours of reperfusion. The organ was isolated and perfused to evaluate liver function. The control group received an intraportal