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Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus

✍ Scribed by William Stohl; Falk Hiepe; Kevin M. Latinis; Mathew Thomas; Morton A. Scheinberg; Ann Clarke; Cynthia Aranow; Frank R. Wellborne; Carlos Abud-Mendoza; Douglas R. Hough; Lilia Pineda; Thi-Sau Migone; Z. John Zhong; William W. Freimuth; W. Winn Chatham; on behalf of the BLISS-52; BLISS-76 Study Groups


Book ID
112002697
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
460 KB
Volume
64
Category
Article
ISSN
0004-3591

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## Abstract Peripheral blood lymphocytes from 14 patients with systemic lupus erythematosus, 5 patients with rheumatoid arthritis, and 10 normal subjects were cultured for 7 days with or without anti‐IgM or anti‐IgD antibodies, and IgG‐ and IgM‐secreting cells were assayed by reverse hemolytic plaq