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Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase ib, double-blind, placebo-controlled, dose-escalating trial

✍ Scribed by Maria Dall'Era; Eliza Chakravarty; Daniel Wallace; Mark Genovese; Michael Weisman; Arthur Kavanaugh; Kenneth Kalunian; Patricia Dhar; Emmanuelle Vincent; Claudia Pena-Rossi; David Wofsy

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 200 KB
Volume: 56
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.23047

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## Abstract ## Objective Serial measurements of anti–double‐stranded DNA (anti‐dsDNA) and complement are routine in the management of systemic lupus erythematosus (SLE), but their utility as biomarkers in preemptive treatment to prevent flares remains a subject of controversy. We hypothesized that