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Beitrag zur Partialsynthese 18-oxygenierter Cortexone I. Synthese von 18-Hydroxy-cortexon Über Steroide, 230. Mitteilung

✍ Scribed by Michel Biollaz; Jaroslav Kalvoda; Julius Schmidlin

Publisher: John Wiley and Sons
Year: 1975
Tongue: German
Weight: 993 KB
Volume: 58
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19750580518

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✦ Synopsis

Abstract

Two improved procedures for the synthesis of 18‐hydroxycortexone and derivatives thereof are presented. One approach involved the development of an efficient method for preparing cyclic 20‐enol ethers as key intermediates for the oxygenation at position 21. In an alternative sequence, starting from a 21‐hydroxypregnene compound, 18‐functionalization has been achieved as the final step by hypoiodite reaction.

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