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Behaviour of dehydroalanine derivatives under hydrazinolysis conditions. Possible relevance to glycoprotein hydrazinolysis

✍ Scribed by Sibel Suzen N; Michael Williams

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 72 KB
Volume: 5
Category: Article
ISSN: 1075-2617
DOI: 10.1002/(sici)1099-1387(199906)5:6<283::aid-psc198>3.0.co;2-o

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✦ Synopsis

Reactions that are relevant to the cleavage, by hydrazinolysis, of O-linked oligosaccharides from glycoproteins were studied using dehydroalanine derivatives as models of the intermediates formed from O-glycosylated serine residues. Conjugate addition of hydrazine followed by cyclisation to form pyrazolidinones, if occurring during glycoprotein hydrazinolysis, could reduce the yield of released oligosaccharide. However, N-acetyldehydroalanine amide derivatives, which modelled the dehydroalanine derivatives believed to be intermediates in the hydrazinolysis of glycoproteins containing O-linked oligosaccharides, underwent conjugate addition but no cyclisation.

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Sibel Suzen and J. Michael Williams, ‘Be

Sibel Suzen and J. Michael Williams, ‘Behaviour of Dehydroalanine Derivatives under Hydrazinolysis Conditions. Possible Relevance to Glycoprotein Hyrdrazinolysis’. Journal of Peptide Science 1999; 5: 283–286

📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 25 KB

The publishers wish to apologise for an error which occurred in Volume 5, Issue 6. The names of the authors of the Short Communication Behaviour of Dehydroalanine Derivatives under Hydrazinolysis Conditions. Possible Relevance to Glycoprotein Hydrazinolysis were published incorrectly on page 283.