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Becker muscular dystrophy recombinant DNA studies in identical twins

✍ Scribed by Victor Ionasescu; Rebecca Ionasescu; Mr. Charles Searby; Dr. Trudy Burns


Book ID
102954167
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
822 KB
Volume
11
Category
Article
ISSN
0148-639X

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The molecular genetics of Duchenne/Becker muscular dystrophy was investigated in 81 affected Turkish families. Deletions were detected by multiplex polymerase chain reaction assays and cDNA Southern analyses. The distribution of the deletions along the gene and their correlation to clinical phenotyp

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The DNA of 33 patients diagnosed as suffering from Becker muscular dystrophy (BMD) has been probed with cloned DNA sequences from Xp21, known to reveal DNA deletions in patients suffering from the more severe Duchenne muscular dystrophy (DMD). Two BMD cases showed clear deletions. A third case gave

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## Communicated by Johan den Dunnen Becker muscular dystrophy (BMD) is a milder form of X-linked Duchenne muscular dystrophy (DMD). Here, we report a study of 75 patients with immunoblot and/or immunostaining findings of muscle biopsy consistent with BMD (abnormal dystrophin). We utilized multiplex