In the present investigation, we studied whether neurotrophin-3 (NT-3) contributes to the rescue of axotomized Clarke's nucleus (CN) neurons in adult rats. A significant (24%) loss of CN neurons occurred at L-1 ipsilateral to T-8 hemisection by 14 days, which reached 31% at 2 months and then stabili
โฆ LIBER โฆ
BDNF abolishes the survival effect of NT-3 in axotomized clarke neurons of adult rats
โ Scribed by Liudmila N. Novikova; Lev N. Novikov; Jan-Olof Kellerth
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 478 KB
- Volume
- 428
- Category
- Article
- ISSN
- 0021-9967
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We used compartmented cultures into NGF plus NT3 compartments, while the combinato study the regulation of adult sensory neurite growth tion of BDNF plus NGF resulted in an inhibition of by neurotrophins. We examined the effects of the neuneurite extension compared with NGF alone. We then rotrophins