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BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

✍ Scribed by Stella M. Ranuncolo; Jose M. Polo; Ari Melnick


Book ID
116304578
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
267 KB
Volume
41
Category
Article
ISSN
1079-9796

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✍ Huifeng Niu πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 103 KB

BCL-6 is an important regulator of the immune system. It is required for GC formation and T cell dependent antibody responses. Mice deficient in BCL-6 fail to form GC and mount reduced levels of T cell-dependent antibody responses. BCL-6 (-/-) mice, in addition, develop a massive inflammatory respon