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The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells

✍ Scribed by Karin Tarte; Michel Jourdan; Jean Luc Veyrune; Ingolf Berberich; Geneviève Fiol; Nicole Redal; John Shaughnessy Jr; Bernard Klein

Book ID: 108672597
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 431 KB
Volume: 125
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2004.04908.x

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mcl-1 was identified as an "early-induction" gene that increases in expression during the differentiation of ML-1 human myeloblastic leukemia cells. The mcl-1 gene product proved to be a member of the bcl-2 gene family and, like bcl-2, to have the capacity to promote cell viability. The pattern of e