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Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance

✍ Scribed by Kelly, JD; Hamilton, PW; McManus, D; Johnston, SR; Williamson, KE

Book ID
109838590
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
175 KB
Volume
78
Category
Article
ISSN
0007-0920

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Bcl-2 is a proto-oncogene which is involved in prolonging cell survival by inhibiting programmed cell death. Bax and bcl-x are members of the bcl-2 family; when overexpressed, they can counteract the ability of bcl-2 to inhibit apoptosis. This suggests a model in which the ratios of bcl-2 to bax and