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Mutant p53 protein, Bcl-2/Bax ratios and apoptosis in paediatric acute lymphoblastic leukaemia

✍ Scribed by G. Srinivas; P. Kusumakumary; M. Krishnan Nair; K. Ramachandra Panicker; M. Radhakrishna Pillai


Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
156 KB
Volume
126
Category
Article
ISSN
1432-1335

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In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Fr