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Bcl-2 sensitive mitochondrial potassium accumulation and swelling in apoptosis

✍ Scribed by Roman A Eliseev; Karlene K Gunter; Thomas E Gunter

Book ID
117798450
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
436 KB
Volume
1
Category
Article
ISSN
1567-7249

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Lonidamine (LND), a selective inhibitor of the energy metabolism of tumor cells, induces apoptosis, independently of the p53 gene, in the adriamycin(ADR)-resistant MCF7 breast-cancer cell line (MCF7 ADR). On the contrary, LND fails to activate the apoptotic program in the parental MCF7-sensitive cel