## Abstract Bclβ2 family members are the arbiters of mitochondrial apoptotic pathway, which is conserved through evolution. The stoichiometry of proβ versus antiapoptotic Bclβ2 family members in the cell determines whether the cell lives or dies. This fine balance is regulated at the transcriptiona
Bcl-2 family proteins and mitochondrial fission/fusion dynamics
β Scribed by Arnaud Autret; Seamus J. Martin
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 418 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
B cell lymphoma gene-2 (Bcl-2) is the prototypic member of a growing family of proteins that play evolutionarily conserved, key regulatory roles in apoptosis. The Bcl-2 family members are characterized by the presence of one or more Bcl-2 homology domains and are comprised of both the prosurvival an
## Abstract Although it has been long recognized that the relative balance of proβ and antiapoptotic Bclβ2 proteins is critical in determining the susceptibility to apoptotic death, only a few studies have examined the level of these proteins specifically at mitochondria during postnatal brain deve