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Bcl-2 and Bax expression and chlorambucil-induced apoptosis in the T-cells and leukaemic B-cells of untreated B-cell chronic lymphocytic leukaemia patients

✍ Scribed by Alun Thomas; Chris Pepper; Terry Hoy; Paul Bentley


Book ID
114118877
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
882 KB
Volume
24
Category
Article
ISSN
0145-2126

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## Abstract B‐cell chronic lymphocytic leukaemia (B‐CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus r