✦ LIBER ✦

Basic science reviews: Tumor suppressor genes

✍ Scribed by Dr. Norris K. Lee

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 879 KB
Volume: 14
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880140513

No coin nor oath required. For personal study only.

✦ Synopsis

Tumor suppressor genes are negative regulators of cell growth. When their normal function is compromised, absence of their inhibitory effects can lead to unrestrained cell cycling and growth. Strong evidence now confirms that loss of proper function of these genes is a common occurrence leading to cancer. Their failure can be caused by alterations in the gene DNA or malfunction of their protein products. The recent extraordinary accumulation of knowledge about these genes reveals that normal carcinogenesis represents breakdown of normal regulatory processes.

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