Basic Esters and Quaternary Derivatives of β-Hydroxy Acids as Antispasmodics 1
✍ Scribed by Treves, Gino R.; Testa, Frank C.
- Book ID
- 126150068
- Publisher
- American Chemical Society
- Year
- 1952
- Tongue
- English
- Weight
- 413 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
A variety of chiral fl-hydroxy-ct-amino acids and derivatives thereof can be synthesized enantioselectively using the aldol reaction of an aldehyde, the glycinate 1 and the cinchonidinederived catalyst 2, as indicated in Schemes I and 2 and Table 1.
Cycloadditions of E-vinylboronic esters la-c bearing an electron withdrawing group in p position to the boronic function with 1,3-butadiene and 2,3\_dimethylbutadiene give smoothly the corresponding Diels-Alder adducts. Functional group manipulations such as oxidation of the carbon-boron bond leads