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Base-promoted reactions of epoxides. I. Isomerization of some cyclic and acyclic epoxides by lithium diethylamide

✍ Scribed by Crandall, Jack K.; Chang, Luan-Ho


Book ID
120323868
Publisher
American Chemical Society
Year
1967
Tongue
English
Weight
757 KB
Volume
32
Category
Article
ISSN
0022-3263

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Unsubstituted medium-ring 1,2-epoxycycloalkanes and certain vie-epoxyalkanes are reduced to the corresponding alcohols very slowly when LiAIH, alone is used as reducing agent. However, the combination of LiA1H4 and AICI,, in a 2:l molar ratio (with respect to 1 mol-equiv. of epoxide) used in refluxi