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Barbitursäurederivate, 23. Mitt. Chirale 1-Methyl-5-butyl-5-phenylbarbitursäure, Enantiomere mit entgegengesetzter zentralnervöser Wirkung

✍ Scribed by Joachim Knabe; Horst P. Büch; Volker Gradmann; Ingrid Wolff

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
261 KB
Volume
310
Category
Article
ISSN
0365-6233

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✍ Joachim Knabe; Horst P. Büch; Georg A. Kirsch 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB

Syntheses of the racemate and the enantiomers of the title compound le are reported. The absolute configuration and the enantiomeric purity of the enantiomers were determined. The enantiomers show opposite central nervous activiiki n animal experiments: the R(-)-enantiomer is anesthetically active,