Baker's yeast reduction of prochiral γ-nitroketones: Enantioselective synthesis of (S)-4-nitroalcohols
✍ Scribed by Antonio Guarna; Ernesto G. Occhiato; Laura M. Spinetti; Maria E. Vallecchi; Dina Scarpi
- Book ID
- 103404873
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 766 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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## Abstract Dialkyl 4‐(dialkoxyphosphoryl)‐3‐oxobutanoates (**__1__**), upon yeast‐mediated bioreduction, afforded chiral dialkyl 4‐(dialkoxyphosphoryl)‐3‐hydroxybutanoates (**__2__**) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4‐(d