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Baker's yeast reduction of 5-acetyl-2-isoxazolines synthesis of enantiomerically pure 2,3-dihydroxy ketones and 1,2,4-triols

✍ Scribed by Calimero Ticozzi; Antonio Zanarotti


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
234 KB
Volume
29
Category
Article
ISSN
0040-4039

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✍ Schrötter, Eberhard ;Weidner, Judith ;Schick, Hans 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

## Abstract 1,3‐Dihydroxy‐3‐methyl‐2‐butanone (1), accessible in 5 steps from 2‐methyl‐3‐butyn‐2‐ol, is reduced by baker's yeast to (__R__)‐(+)‐3‐methyl‐1,2,3‐butanetriol (2) with a high enantioselectivity. This chiral building block for the synthesis of various sterols with a modified side chain t