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Bacterial proteinases as targets for the development of second-generation antibiotics

โœ Scribed by James Travis; Jan Potempa


Book ID
114150122
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
485 KB
Volume
1477
Category
Article
ISSN
0167-4838

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Second generation analogs of rigid 6,7-s
โœ Christos I. Stathakis; Ioannis Mavridis; Georgia Kythreoti; Athanasios Papakyria ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 695 KB

Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalizatio