Bacterial CMP-sialic acid synthetases: production, properties, and applications
β Scribed by Rahman M. Mizanur; Nicola L. Pohl
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 223 KB
- Volume
- 80
- Category
- Article
- ISSN
- 1432-0614
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π SIMILAR VOLUMES
## Abstract Sialyloligosaccharides are synthesised by various glycosyltransferases and sugar nucleotides. All of these nucleotides are diphosphate compounds except for cytidineβ5β²βmonophosphosialic acid (CMPβNeu5Ac). To obtain an insight into why cytidineβ5β²βdiphosphosialic acid (CDPβNeu5Ac) has no
Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to inhibit the 9-O-acetylsialic acid esterase from influenza C virus in a competitive manner with a K~ of 4.2+0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase.