✦ LIBER ✦

Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia

✍ Scribed by Joseph L. Wiemels; Michelle Kang; Jeffrey S. Chang; Lily Zheng; Carina Kouyoumji; Luoping Zhang; Martyn T. Smith; Ghislaine Scelo; Catherine Metayer; Patricia Buffler; John K. Wiencke

Book ID: 116304797
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 355 KB
Volume: 45
Category: Article
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2010.07.007

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

High hyperdiploid childhood acute lympho

High hyperdiploid childhood acute lymphoblastic leukemia

✍ Kajsa Paulsson; Bertil Johansson 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 498 KB

## Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL), occurring in 25–30% of such cases. High hyperdiploid ALL is characterized cytogenetically by a nonrandom gain of chromosomes X, 4,

CREBBP HAT domain mutations prevail in r

CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia

✍ Inthal, A; Zeitlhofer, P; Zeginigg, M; Morak, M; Grausenburger, R; Fronkova, E; 📂 Article 📅 2012 🏛 Nature Publishing Group 🌐 English ⚖ 480 KB

Comparative expressed sequence hybridiza

Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia

✍ Alicja M. Gruszka-Westwood; Sharon W. Horsley; Angel Martinez-Ramirez; Christine 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 613 KB

## Abstract The functional consequences of a high‐hyperdiploid karyotype, found in up to one‐third of cases of acute lymphoblastic leukemia (ALL), are unknown. Using the technique of comparative expressed sequence hybridization (CESH), we sought to address the question of whether increased chromoso

Relapsed childhood high hyperdiploid acu

Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations

✍ Davidsson, J; Paulsson, K; Lindgren, D; Lilljebjörn, H; Chaplin, T; Forestier, E 📂 Article 📅 2010 🏛 Nature Publishing Group 🌐 English ⚖ 411 KB

RAS oncogene mutations and outcome of th

RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia

✍ Perentesis, J P; Bhatia, S; Boyle, E; Shao, Y; Shu, X Ou; Steinbuch, M; Sather, 📂 Article 📅 2004 🏛 Nature Publishing Group 🌐 English ⚖ 262 KB

Mutations of FLT3, NRAS, KRAS, and PTPN1

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia

✍ Kajsa Paulsson; Andrea Horvat; Bodil Strömbeck; Fredrik Nilsson; Jesper Heldrup; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

## Abstract Although it has been suggested that mutations of the __FLT3__, __NRAS__, __KRAS__, and __PTPN11__ genes are particularly frequent in high hyperdiploid (>50 chromosomes) pediatric acute lymphoblastic leukemias (ALLs), this has as yet not been confirmed in a large patient cohort. Furtherm