Backbone NMR Assignment of the Low-molecular-weight Protein Tyrosine Phosphatase (MPtpA) fromMycobacterium Tuberculosis
β Scribed by Krishna Saxena; Bettina Elshorst; Holger Berk; Marco Betz; Susanne Grimme; Thomas Langer; Barbara Pescatore; Ulrich Schieborr; Martin Vogtherr; Harald Schwalbe
- Book ID
- 106401192
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Weight
- 166 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0925-2738
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Molecular dynamics simulation of the Michaelis complex, phospho-enzyme intermediate, and the wild-type and C12S mutant have been carried out to examine hydrogen-bonding interactions in the active site of the bovine low molecular weight protein-tyrosine phosphatase (BPTP). It was found that the S Ξ³ a
## Abstract The marine plitidepsin Aplidin derived from the Mediterranean tunicate __Aplidium albicans__ is a strong apoptotic inducer with promising antitumor activity. However, little is known about the mechanism of action of the molecule. In this article, we report that Aplidin is cytotoxic for