𝔖 Bobbio Scriptorium
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Baboon anti-idiotype antibodies mimic a carcinoembryonic antigen epitope

✍ Scribed by Michele J. Losman; Marc Monestier; Hans J. Hansen; David M. Goldenberg

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
560 KB
Volume
46
Category
Article
ISSN
0020-7136

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✦ Synopsis

A baboon was immunized with NP-4, a murine monoclonal antibody (MAb) to carcinoembryonic antigen (CEA). Antiidiotype antibodies were purified from the baboon serum by affinity chromatography on a NP-+coupled matrix, followed by adsorption of the non-specific antibodies on an irrelevant MAb. Baboon anti-idiotype antibodies inhibited specifically the binding between NP-4 and CEA. Mice immunized with baboon anti-idiotype antibodies produced antibodies to the CEA epitope recognized by NP-4. These results indicate that baboon anti-idiotype antibodies functionally mimic a CEA epitope and that they can be suitable for idiotype therapy of human CEA-producing carcinomas.

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