We have previously isolated and characterized 6 anti-idiotype antibodies (Ab2s) directed against monoclonal antibody G250 (MAbG250) which reacts with a tumor-associated antigen (TAA) expressed in a large proportion of human renal-cell carcinomas (RCC). These 6Ab2s (NUH31,51,71,82,91: IgG,, NUH44: Ig
A monoclonal anti-idiotypic antibody bearing the image of an epitope specific to the human carcinoembryonic antigen
β Scribed by Franz-Josef Gaida; Ursula Fenger; Christoph Wagener; Michael Neumaier
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Volume
- 51
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
MATERIAL AND METHODS ## Reagents PtdIns and BSA were purchased from Sigma (St Louis, MO). Freund's complete (Bacto H37 Ra) and incomplete adjuvants were purchased from DIFCO (Detroit, MI).
## Abstract The monoclonal antibody (F10β89β4) described in this study recognizes an antigen which by quantitative absorption analysis is absent from human brain, kidney, liver, heart, erythrocytes, platelets and normal serum, but is present on spleen, lymph node, chronic lymphatic leukemia cells,
There is accumulating evidence that cellular rather than antibody responses are more effective for tumour rejection. It is therefore important to screen anti-idiotypic (anti-id) antibodies for their ability to stimulate anti-tumour T-cell responses. The human anti-id monoclonal antibody (MAb) I05AD7