B-Z transition of poly(dG-m5dC).poly(dG-m5dC) in the presence of basic oligopeptides
✍ Scribed by Hana Votavová; Jaroslav Šponar
- Book ID
- 116091474
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 548 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0141-8130
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The effect of basic oligopeptides (Lys-Ala-Ala), ( n = 1-5,10) and ( Lys-Leu-Ala), ( n = 1-4 ) on the B-Z transition of poly (dG-dC) .poly( dG-dC) in water-methanol solutions was investigated using CD and uv spectroscopy: In the absence of peptides, the concentration of methanol at the midpoint of t
## Abstract The double‐stranded helical complexes of poly(dG‐dC) and of poly(dG‐m^5^dC) are shown to convert from B‐ to Z‐DNA‐type conformations at moderate or low ionic strengths, lower for the 5‐methyl than for the non‐methyl species, in a highly cooperative temperature‐dependent equilibrium. In