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B cell therapy with the anti-CD22 monoclonal antibody epratuzumab: Comment on the editorial by St.Clair and Tedder

✍ Scribed by David M. Goldenberg; Rhona Stein; John P. Leonard; Serge D. Steinfeld; Thomas Dörner; Gerd R. Burmester


Book ID
101648747
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
34 KB
Volume
54
Category
Article
ISSN
0004-3591

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CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism o