B Cell Receptor Signaling

✍ Scribed by Tomohiro Kurosaki, Jürgen Wienands (eds.)

Publisher: Springer International Publishing
Year: 2016
Tongue: English
Leaves: 231
Series: Current Topics in Microbiology and Immunology 393
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca²⁺ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

✦ Table of Contents

Front Matter....Pages i-viii
Assembly and Function of the Precursor B-Cell Receptor....Pages 3-25
Receptor Dissociation and B-Cell Activation....Pages 27-43
Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis....Pages 45-63
BTK Signaling in B Cell Differentiation and Autoimmunity....Pages 67-105
The Memory Function of the B Cell Antigen Receptor....Pages 107-121
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)....Pages 123-142
Role of Calcium Signaling in B Cell Activation and Biology....Pages 143-174
Roles of the NF-κB Pathway in B-Lymphocyte Biology....Pages 177-209
MAP Kinase Cascades in Antigen Receptor Signaling and Physiology....Pages 211-231

✦ Subjects

Immunology; Molecular Medicine; Cancer Research

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