✦ LIBER ✦

B cell development and receptor diversity during aging

✍ Scribed by David Allman; Juli P Miller

Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 105 KB
Volume: 17
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2005.07.002

No coin nor oath required. For personal study only.

✦ Synopsis

Although it is clear that B cell genesis declines with age, the specifics of why this happens are largely unknown. Even less clear is how the age-related decline in B cell development might affect peripheral B cell function. Recent studies have investigated the impact of aging on both B cell genesis in the bone marrow and the resulting peripheral B cell repertoire. On the basis of these studies we propose a model in which the aging of very early B cell progenitors results in shifts in the peripheral B cell repertoire and, consequently, changes in mature B cell function.

📜 SIMILAR VOLUMES

T cell development and receptor diversit

T cell development and receptor diversity during aging

✍ Jörg J Goronzy; Cornelia M Weyand 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 276 KB

The T cell system is a complex and highly dynamic system that is amazingly robust over many decades of human life. Its functional competence is determined not only by its size but also by its diversity. Homeostatic control mechanisms have to secure sufficient T cell replenishment while preventing lo

Elastic fiber during development and agi

Elastic fiber during development and aging

✍ Pasquali-Ronchetti, I.; Baccarani-Contri, M. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 453 KB

Elastin molecules aggregate in the extracellular space where they are crosslinked by stable desmosine bridges. The resulting polymer is structurally organized as branched fibers and lamellae, which, in skin, are wider (a few microns) in the deep dermis and become progressively thinner (fraction of a

Novel cell surface receptors during mamm

Novel cell surface receptors during mammalian fertilization and development

✍ Helen J. Hathaway; Barry D. Shur 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 817 KB

Kuo, M. T. (1983). Isolation and preliminary chardcterization of the synaptonemal complex from rat pachytene spermatocytes. Exp Cell Res 144, 63-12. 4 CARPENTER, A. T. C. (1979). Synaptonemal complex and recombination nodules in wild-type Drosophila melanogaskr females. Generics 92. 51 1-541. 5 ALBI

Memory T cell homeostasis and senescence

Memory T cell homeostasis and senescence during aging

✍ Arne N Akbar; Jean M Fletcher 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 318 KB

Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are driven to exhaustion in

Diversity and antigen specificity of the

Diversity and antigen specificity of the T cell receptor

✍ L.A. Matis 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 655 KB

Impaired B-1 and B-2 B cell development

Impaired B-1 and B-2 B cell development and atypical splenic B cell structures in IL-7 receptor-deficient mice

✍ Lena Erlandsson; Steve Licence; Fabrina Gaspal; Sarah Bell; Peter Lane; Anne E. 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB

## Abstract The cytokine IL‐7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL‐7 receptor α‐deficient mice. We demonstrate that the IL‐7 receptor becomes progressively more important with age.