✦ LIBER ✦

B-cell development: a comparison between mouse and man

✍ Scribed by Paolo Ghia; Edwin ten Boekel; Antonius G. Rolink; Fritz Melchers

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 681 KB
Volume: 19
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(98)01330-9

No coin nor oath required. For personal study only.

✦ Synopsis

A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component lambda 5/14.1, shows a similar phenotype of B-cell deficiency as the lambda 5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.

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