Synthesis and biological activity of pyr
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Robert M. Tynebor; Meng-Hsin Chen; Swaminathan R. Natarajan; Edward A. O’Neill;
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Article
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2011
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Elsevier Science
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English
⚖ 705 KB
The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.