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Azulene analogs of pharmacological agents III: Acute toxicity and local anesthetic activity of azulylamides and azulenecarboxamides

โœ Scribed by P. H. Doukas; T. J. Speaker; R. S. Thompson


Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
351 KB
Volume
64
Category
Article
ISSN
0022-3549

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Local anesthetic activity and acute toxi
โœ H. Jack Adams; George H. Kronberg; Bertil H. Takman ๐Ÿ“‚ Article ๐Ÿ“… 1972 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 286 KB

This paper is concerned with the local anesthetic activity and acute toxicity of (+~)-2-(N-ethylpropylamino)-2',6'-butyroxylidide (I). Testing in rat sciatic nerve blocks and guinea pig intradermal wheals showed that the compound has rapid onset, excellent frequency, and long durations of block. The