๐”– Bobbio Scriptorium
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AZT-induced mitochondrial myopathy

โœ Scribed by G. Tomelleri; P. Tonin; M. Spadaro; G. Tilia; D. Orrico; A. Barelli; B. Bonetti; S. Monaco; A. Salviati; C. Morocutti; N. Rizzuto


Book ID
105504000
Publisher
Springer Milan
Year
1992
Tongue
English
Weight
956 KB
Volume
13
Category
Article
ISSN
1590-1874

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The possibility of tissue-speciยฎc eects regarding mitochondrial sensitivity to AZT was evaluated in this study. When mitochondria isolated from liver, kidney, skeletal and cardiac muscle were oxidizing glutamate, a dose-dependent inhibition by AZT of state 3 respiration was observed; using succinate