𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Azo-dye carcinogenesis. The reactions of 4-hydroxymethylaminoazobenzene with cytosine derivatives

✍ Scribed by J. J. Roberts; G. P. Warwick

Publisher
John Wiley and Sons
Year
1966
Tongue
French
Weight
834 KB
Volume
1
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

A mixture of formaldehyde and aminoazobenzene condensed readily under physiological conditions to form covalently bound products with purines or pyrimidines and their corresponding nucleosides and nucleotides bearing amino groups. In the case of cytosine derivatives it was established that Mannich type condensations occurred with the pyrimidine amino group and the N-I position to form substituted triazines, derived from two molecules of formaldehyde, one of aminoazobenzene and one of the corresponding pyrimidine. The triazine ring structure derived from cytosine was stable at p H values greater than 7, while those derived from cytosine nuczeosides and nucleotides opened at the N-I position at p H 9. At higher p H values decomposition of these substituted cytosine rings occurred, accompanied by hydrolysis of both methylene bonds. All compounds were hydrolysed by dilute mineral acid into the original constituents. The properties of these in vitro condensation products were compared to those formed by reaction of metabolites of 4-dimethylaminoazo [G-3H]-benzene with R N A in vivo with respect to their stability at diflerent p H values.

📜 SIMILAR VOLUMES

Genetic properties of substituted deriva
Genetic properties of substituted derivatives of N-methyl-4-aminoazobenzene in relation to azo-dye carcinogenesis
✍ O. G. Fahmy; Myrtle J. Fahmy 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 983 KB

## Abstract A comparative genetic study was undertaken with structurally related N‐methyl‐4‐aminoazobenzenes of varied chemical reactivities and carcinogenicities, including the parent N, N‐dimethyl azo dye (butter yellow) and model compounds of its suspected metabolites. The mutagenic activity of

The reaction of furan derivatives with a
The reaction of furan derivatives with azo-bis-isobutyronitrile
✍ A. Gandini; J. Rieumont 📂 Article 📅 1976 🏛 Elsevier Science 🌐 French ⚖ 210 KB

The interaction of free radicals with furan has been studied previously, but only with alkaxy (11, bcnzoyl (2) and aromatic radicals (3-5). The addition reactions to give 2,5\_dihydrofurans predominate, but in the case of the phenyl radicals (3-5) substitution at C-2 has been reported. The mechanis

Quantitative Gas-Solid Diazotization of
Quantitative Gas-Solid Diazotization of 3-Aminopyrazolo[3,4-b]pyridine Derivatives and Azo Dye Syntheses by Means of Solid-Solid Reactions
✍ Gerd Kaupp; Mohamed Abbas Metwally; Fathy A. Amer; Ehab Abdel-latif 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

## Abstract Gas‐solid and solid‐solid techniques allow for waste‐free quantitative syntheses and coupling reactions of the heterocyclic diazonium salts **2**. The solid‐state diazotization of **1a** with gaseous NO~2~ has been mechanistically investigated by atomic force microscopy (AFM). Azo coupl