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Aziridines as templates: A general strategy for the stereospecific synthesis of 2-azetidinones

✍ Scribed by S. D. Sharma; Seema Kanwar; Shivani Rajpoot

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
147 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Various routes to a variety of azridine‐2‐carboxylates have been described and the stereochemistry of these compounds has been determined by spectroscopic methods. Further, greater diversity of β‐lactams via ring expansion of these azridines‐2‐carboxylates were obtained by a general, efficient and direct stereospecific approach.

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A general and versatile synthesis of 3-p
A general and versatile synthesis of 3-phenylthio β-lactams as lead molecules for 3-methyl-2-azetidinones
✍ Seema Kanwar; S. D. Sharma 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 466 KB

## Abstract magnified image Ketene‐imine cycloaddition using phosphorus oxychloride and benzenesulfonyl chloride under the described reaction conditions yielded __trans__ 3‐phenylthio 2‐azetidinones in good yields. Desulfurization using Raney nickel and alkylation finally afforded __trans__ 3‐meth