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Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking

✍ Scribed by Rachel C. LePla; Cyrille A.S. Landreau; Michael Shipman; John A. Hartley; George D.D. Jones


Book ID
108073634
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
228 KB
Volume
15
Category
Article
ISSN
0960-894X

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## Abstract Studies were performed to determine whether novobiocin can be used to enhance cisplatin (CDDP) cytotoxicity in a human small‐cell lung carcinoma cell line, GLC~4~/CDDP, resistant to CDDP. Continuous incubation with novobiocin enhanced the cytotoxicity of CDDP treatment 1.9‐fold in the p