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Effect of novobiocin on cisplatin cytotoxicity and DNA interstrand cross-link formation in a cisplatin-resistant, small-cell lung carcinoma cell line


Book ID
123564098
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
153 KB
Volume
10
Category
Article
ISSN
0169-5002

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Effect of novobiocin on cisplatin cytoto
✍ Steven De Jong; Hetty Timmer-Bosscha; Elisabeth G. E. De Vries; Nanno H. Mulder πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 948 KB

## Abstract Studies were performed to determine whether novobiocin can be used to enhance cisplatin (CDDP) cytotoxicity in a human small‐cell lung carcinoma cell line, GLC~4~/CDDP, resistant to CDDP. Continuous incubation with novobiocin enhanced the cytotoxicity of CDDP treatment 1.9‐fold in the p