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Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells

✍ Scribed by Schallreuter, Karin U.; Wood, J.M.

Book ID
121194049
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
593 KB
Volume
36
Category
Article
ISSN
0304-3835

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Cytosolic thioredoxin reductase (TrxR, EC 1.6.4.5) is a FADbound homodimeric oxidoreductase structurally and mechanistically related to glutathione reductase (GR, EC 1.8.1.7). TrxR uses NADPH as an electron donor, and is able to reduce a range of substrates including the physiological thioredoxin (T