Azathioprine, 6-mercaptopurine and thiopurine S-methyltransferase
β Scribed by IC ROBERTS-THOMSON; WJ BUTLER
- Book ID
- 108950417
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 30 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0815-9319
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π SIMILAR VOLUMES
The therapeutic use of the immunosuppressive drug Azathioprine (AZA) in preventing rejection in allograft transplant recipients is limited by its haematological toxicity, mainly leukopenia. AZA is a "prodrug", spontaneously converted in the body to two derivatives, 6 mercaptopurine (6MP), and a nit
Daily 6-mercaptopurine (6MP) forms the backbone of continuing chemotherapy for childhood lymphoblastic leukaemia (ALL). A major metabolic route is catalysed by thiopurine methyltransferase (TPMT). TPMT deficiency occurs in 1 in 300 individuals and results in high concentrations of thioguanine nucleo