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Azathioprine, 6-mercaptopurine and thiopurine S-methyltransferase

✍ Scribed by IC ROBERTS-THOMSON; WJ BUTLER


Book ID
108950417
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
30 KB
Volume
20
Category
Article
ISSN
0815-9319

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The therapeutic use of the immunosuppressive drug Azathioprine (AZA) in preventing rejection in allograft transplant recipients is limited by its haematological toxicity, mainly leukopenia. AZA is a "prodrug", spontaneously converted in the body to two derivatives, 6 mercaptopurine (6MP), and a nit

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Daily 6-mercaptopurine (6MP) forms the backbone of continuing chemotherapy for childhood lymphoblastic leukaemia (ALL). A major metabolic route is catalysed by thiopurine methyltransferase (TPMT). TPMT deficiency occurs in 1 in 300 individuals and results in high concentrations of thioguanine nucleo