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Aza analogs of lucanthone: synthesis and antitumor and bactericidal properties

โœ Scribed by Croisy-Delcey, Martine; Bisagni, Emile


Book ID
120560674
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
671 KB
Volume
26
Category
Article
ISSN
0022-2623

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Synthesis and antitumor activity of podo
โœ Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 157 KB

## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin