Disialoganglioside GD2 is widely expressed among neuroblastomas, melanomas, small-cell lung carcinoma, sarcomas and brain tumors. Immunity directed against this antigen may have anti-tumor utility. Since GDz is poorly immunogenic, antiidiotypic antibodies may serve as alternative tumor vaccines. Mon
Availability of conjugated ganglioside GD2 monoclonal antibody
โ Scribed by Michael J. Warzynski; John L. Roys; John W. Peterson; Humberto DeLa Vega
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 126 KB
- Volume
- 65B
- Category
- Article
- ISSN
- 1552-4949
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โฆ Synopsis
We published in the journal a new four-color flow cytometric method to help diagnose, stage, monitor, and screen autologous transplant products for children with neuroblastoma (1). The ''four-color'' monoclonal antibody assay involved a ganglioside GD2/fluorescein isothiocyanate (FITC), TAPA CD81/phycoerythrin, leukocytic CD45/
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We have recently reported that the disialoganglioside GD3 is found in cellular lipid extracts of T-cell acute lymphoblastic malignancies (T-ALL) but is not detectable by resorcinol staining in extracts of non-T acute lymphoblastic leukemia blasts (non-T-ALL). We have now extended this study to asses
Substantial concentrations of the cell-surface glycosphingolipid, the disialoganglioside GD2, are uniformly present in human neuroblastoma tumors. This ganglioside can also be detected in the plasma of patients with neuroblastoma by direct thin-layer chromatographic analysis. Among 32 neuroblastoma
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