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Auxiliary mediated synthesis of aziridine-2-carboxylic acid derivatives

✍ Scribed by Philip Garnet; Ozdemir Dogan; Satish Pillai


Book ID
103409213
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
397 KB
Volume
35
Category
Article
ISSN
0040-4039

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Aziridine 2-Carboxylate Ester Mediated Asymmetric Synthesis of Ξ±-Alkyl Ξ²-Amino Acids. -Highly stereoselective reductive ring opening of the N-tosylaziridines (II) with LiAlH4 followed by oxidation of the syn-amino alcohols (III) provides an efficient entry to the asymmetric synthesis of Ξ±methyl Ξ²-am