Three p o p u l a t i o n s of r e t a r d e d i n d i v i d u a l s were s u rveyed and t h e f r e q u e n c y of t h e f r a (X) w a s found t o b e 1 . 9 % i n males and 0.3% i n females. STUDY POPULATIONS W e have completed s u r v e y s of 3 p o p u l a t i o n s of m e n t a l l y r e t a r d
Autosomal folate sensitive fragile sites in normal and mentally retarded individuals in Greece
โ Scribed by Mavrou, Ariadni ;Syrrou, Maria ;Tsenghi, Christine ;Metaxotou, Catherine
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 280 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0148-7299
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Expression of the fragile site fra(X) ( q 2 7 . 3 ) in peripheral lymphocytes was evaluated in mentally retarded patients and in normal control individuals before and after administration of the antifolic agent trimethoprim for 7 days. This treatment was effective in converting the status of some in
This study presents the first large, population-based molecular investigation of the fragile X (FRAXA) and FRAXE mental retardation syndromes in the Hellenic populations of Greece and Cyprus. The aims of this population screening were to determine the prevalence of FRAXA and FRAXE syndromes among id