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Autoregulation of the nar operon encoding nitrate reductase in Escherichia coli

✍ Scribed by Bonnefoy, Violaine ;Pascal, Marie-Claire ;Ratouchniak, Jeanine ;Chippaux, Marc


Publisher
Springer
Year
1986
Tongue
English
Weight
469 KB
Volume
204
Category
Article
ISSN
0026-8925

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✦ Synopsis


Nitrate reductase is demonstrated to exert an autogenous control on its own synthesis. This effect requires the participation of the molybdenum cofactor. Use of strains in which the control region of the nar operon is mutated reveals two loci in this region: one, affected in strain LCB94, is common to both autoregulation and induction by nitrate while the other, mutated in strain LCB188, is specific for the induction by nitrate. It is proposed that the autogenous control prevents the unnecessary accumulation of the nitrate reductase subunits in the cytoplasm.


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