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Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function

✍ Scribed by Lorna B. Jarvis; Malgosia K. Matyszak; Richard C. Duggleby; Jane C. Goodall; Frances C. Hall; J. S. Hill Gaston


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
407 KB
Volume
35
Category
Article
ISSN
0014-2980

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## Abstract Treatment with anti‐CD3 mAb modulates immune responses that cause type 1 diabetes and other diseases. CD8^+^ Tregs can be induced in vitro and in vivo by mAb. However, 1/3 of patients do not respond to drug therapy and in an equal proportion, anti‐CD3 mAb does not induce Tregs in vitro.