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Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

✍ Scribed by Natalia B. Nedelsky; Peter K. Todd; J. Paul Taylor

Book ID
116270696
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
562 KB
Volume
1782
Category
Article
ISSN
0925-4439

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## Abstract Proinflammatory cytokine TWEAK has now emerged as a key mediator of skeletal muscle‐wasting in many catabolic conditions. However, the mechanisms by which TWEAK induces muscle proteolysis remain poorly understood. Here, we have investigated the role of ubiquitin‐proteasome system, autop