Autonomic regulation in fragile X syndrome
β Scribed by Keri J. Heilman; Emily R. Harden; Danielle M. Zageris; Elizabeth Berry-Kravis; Stephen W. Porges
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 193 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0012-1630
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## Abstract Fragile X syndrome, the most common genetic disorder associated with mental retardation is caused by an expansion of the unstable CGG repeat within the __FMR1__ gene. Although overgrowth is not the main hallmark of this condition, the fragile X syndrome is usually included in the differ
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Laird et al. (1987) hypothesized that there are at least four cis-acting alleles or 'chromosome states' at Xq27 that increasingly delay replication at this chromosomal area resulting in its increasing fragility in vitro. When on the inactive X chromosome, the proposed third ('mutated') allele can