Sleep apnea in fragile X syndrome

✍ Scribed by Tirosh, Emanuel ;Borochowitz, Zvi

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 326 KB
• Volume: 43
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/ajmg.1320430119

✦ Synopsis

o b s t r u c t i v e s l e e p apnea (OSA). A f t e r a s t r u ctured interview, 4 of them underwent an overnight polygraphic study. The r e s u l t s i n d i c a t e an increased r i s k f o r OSA among subjects with fra(X) ( 4 / 7 ) . In 2 of t h e s u b j e c t s polygraphic study indicated a severe OSA syndrome, whereas only mild and moderate s e v e r i t y w a s evident i n the o t h e r two. Apnea i n a l l 4 was a s s o c i a t e d with s i g n i f i c a n t O2 d e s a t u r a t i o n . Episodes of prolonged exp i r a t o r y apnea were reported i n 2 of t h e s u b j e c t s and confirmed by t h e polygraphic study i n one. A continuous p o s i t i v e airway pressure (C-PAP) t r i a l was successful i n one of t h e two p a t i e n t s . I t i s suggested t h a t s u b j e c t s with f r a ( X ) are a t increased r i s k f o r OSA, and physicians should o r i e n t a t e their evaluation with t h i s i n mind.