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Automated Process Research and the Optimization of the Synthesis of 4(5)-(3-Pyridyl)imidazole

โœ Scribed by Kirchhoff, Eric W.; Anderson, Denise R.; Zhang, Songlei; Cassidy, Constance S.; Flavin, Michael T.


Book ID
127271025
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
69 KB
Volume
5
Category
Article
ISSN
1083-6160

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a b s t r a c t Heating a neat 1:2 mixture of 2-picolylamine and 2-cyanopyridine followed by treatment of the resultant red gummy substance with aqueous KOH resulted in the isolation of 2,4,5-tris(2-pyridyl)imidazole (1a) as the major product and N-(3-(2-pyridyl)imidazo[1,5-a]pyridine)picolinamidine